CHD5 , a Tumor Suppressor Gene Deleted From 1p36.31 in Neuroblastomas
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چکیده
منابع مشابه
CHD5, a Tumor Suppressor Gene Deleted From 1p36.31 in Neuroblastomas
BACKGROUND Neuroblastomas are characterized by hemizygous 1p deletions, suggesting that a tumor suppressor gene resides in this region. We previously mapped the smallest region of consistent deletion to a 2-Mb region of 1p36.31 that encodes 23 genes. Based on mutation analysis, expression pattern, and putative function, we identified CHD5 as the best tumor suppressor gene candidate. METHODS W...
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Novel CHD5, a tumor suppressor gene in neuroblastomas Neuroblastoma, a tumor of the sympathetic nervous system, is the most common childhood extracranial solid tumor. The authors have identified different patterns of genetic change that underlie these disparate clinical behaviors. One of the most characteristic genetic changes in neuroblastomas is deletion of the short arm of hromosome 1 (1p). ...
متن کاملRole of microRNAs in epigenetic silencing of the CHD5 tumor suppressor gene in neuroblastomas
Neuroblastoma (NB), a tumor of the sympathetic nervous system, is the most common extracranial solid tumor of childhood. We and others have identified distinct patterns of genomic change that underlie diverse clinical behaviors, from spontaneous regression to relentless progression. We first identified CHD5 as a tumor suppressor gene that is frequently deleted in NBs. Mutation of the remaining ...
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BACKGROUND Clusterin expression in various types of human cancers may be higher or lower than in normal tissue, and clusterin may promote or inhibit apoptosis, cell motility, and inflammation. We investigated the role of clusterin in tumor development in mouse models of neuroblastoma. METHODS We assessed expression of microRNAs in the miR-17-92 cluster by real-time reverse transcription-polym...
متن کاملMechanisms of CHD5 Inactivation in neuroblastomas.
PURPOSE Neuroblastomas (NBs) have genomic, biological, and clinical heterogeneity. High-risk NBs are characterized by several genomic changes, including MYCN amplification and 1p36 deletion. We identified the chromatin-remodeling gene CHD5 as a tumor suppressor gene that maps to 1p36.31. Low or absent CHD5 expression is associated with a 1p36 deletion and an unfavorable outcome, but the mechani...
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ژورنال
عنوان ژورنال: JNCI: Journal of the National Cancer Institute
سال: 2008
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/djn176